028 Methotrexate induced necrotising lymphangitis

Filarial Lymphangitis

Creeping lymphangitis.

A 35 year old man presented with a two day history of a tender rash on the right thigh. Examination showed serpiginous erythema extending from a vesiculopustule on his right thigh. Staphylococcus aureus was identified in a culture of the vesiculopustular fluid. The diagnosis of lymphangitis spreading from folliculitis was made. The patient was successfully treated with oral ampicillin. Learning...

Cutaneous necrotising vasculitis induced by levamisole.

A 59-year-old woman had been receiving thrice-weekly levamisole 150 mg/day for three months, when in May 1975 she developed fever and a severe rash. Cutaneous necrotising vasculitis was diagnosed. Biopsy of one of the lesions showed intense neutrophil and eosinophil infiltration of the vessel wall with obliteration of the lumen. There were no other physical abnormalities, and no sign of the ori...

Methotrexate induced accelerated nodulosis.

Methotrexate induced accelerated nodulosis (MIAN) is a rare but unique side effect of methotrexate therapy. There is paucity of data from our country about this entity. We analyzed 14 cases of MIAN and studied its association with gender, rheumatoid factor positivity and dose and duration of methotrexate. Fourteen patients (8 females), 12 with rheumatoid arthritis (8 seropositive), one each wit...

Methotrexate Induced Pancytopenia

The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become proble...